GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11148252 | 1 | rs4886018 | chr13:52990717 | CKAP2 | chr13:53029495-53050763:+ | -0.65 | -17.65 | 4.62E-54 | Lewy body disease |
| THCA | cis | rs11148252 | 1 | rs4886018 | chr13:52990717 | NEK3 | chr13:52706780-52733996:- | 0.2 | 4.89 | 1.36E-6 | Lewy body disease |
| THCA | cis | rs11148252 | 1 | rs4886018 | chr13:52990717 | VPS36 | chr13:52986739-53024763:- | 0.19 | 4.85 | 1.69E-6 | Lewy body disease |
| THCA | cis | rs936229 | 1 | rs4886615 | chr15:75131661 | CSK | chr15:75074425-75095539:+ | -0.1 | -3.47 | 0.000562 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THCA | cis | rs936229 | 1 | rs4886615 | chr15:75131661 | MPI | chr15:75182410-75190565:+ | 0.32 | 6.82 | 2.72E-11 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THCA | cis | rs936229 | 1 | rs4886615 | chr15:75131661 | ULK3 | chr15:75128459-75135552:- | -0.16 | -4.74 | 2.89E-6 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THCA | cis | rs2404602 | 1 | rs4886818 | chr15:76880939 | SCAPER | chr15:76640529-77197744:- | -0.17 | -5.62 | 3.28E-8 | Blood metabolite levels |
| THCA | cis | rs4887067 | 1 | rs4887067 | chr15:78886947 | CHRNA5 | chr15:78857906-78886458:+ | -0.42 | -8.3 | 1.08E-15 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs4888262 | 1 | rs4887783 | chr16:74700743 | RFWD3 | chr16:74655298-74700779:- | -0.31 | -8.21 | 2.1E-15 | Testicular germ cell tumor |
| THCA | cis | rs7116495 | 1 | rs488799 | chr11:71561686 | FAM86C | chr11:71498557-71512276:+ | -0.37 | -4.34 | 1.73E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs4888262 | 1 | rs4888262 | chr16:74670458 | RFWD3 | chr16:74655298-74700779:- | -0.3 | -7.86 | 2.53E-14 | Testicular germ cell tumor |
| THCA | cis | rs4888262 | 1 | rs4888264 | chr16:74681632 | RFWD3 | chr16:74655298-74700779:- | -0.31 | -7.96 | 1.29E-14 | Testicular germ cell tumor |
| THCA | cis | rs4888262 | 1 | rs4888265 | chr16:74683737 | RFWD3 | chr16:74655298-74700779:- | -0.3 | -7.62 | 1.39E-13 | Testicular germ cell tumor |
| THCA | cis | rs4888671 | 1 | rs4888667 | chr16:77779480 | NUDT7 | chr16:77756411-77776153:+ | 0.37 | 5 | 8.06E-7 | Obesity-related traits |
| THCA | cis | rs4888671 | 1 | rs4888668 | chr16:77779481 | NUDT7 | chr16:77756411-77776153:+ | 0.37 | 5 | 8.06E-7 | Obesity-related traits |